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Zach Klaassen· @zklaassen_md · X·· 2 days agoScore70

KEYNOTE-365

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Updated results from Ph 1b/2 KEYNOTE-365 Cohort I: Pembro + Chemo (n=40) vs Chemo (n=30) for NEPC @urotoday #ESMO26

Pembro + Chemo vs Chemo:
📌ORR: 28% vs 15%
📌DCR: 50% vs 48%
📌Med DOR: 6.2 vs 4.1 mos
📌m-rPFS: 5.1 vs 4.0 mos; HR 0.66, 95%CI 0.36-1.21
📌mOS: 10.2 vs 7.1 mos; HR 0.33, 95%CI 0.17-0.63

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Conference abstracts
2217RONCT04746300matched by Rapid oral: Genitourinary tumours, prostate, penile and testis

Updated results from the phase 1b/2 KEYNOTE-365 cohort I: Pembrolizumab (pembro) + carboplatin and etoposide chemotherapy (chemo) or chemo alone for neuroendocrine prostate cancer (NEPC)

https://esmocongress.esmo.org

Source: Zach Klaassen · x.com

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