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Grainne O'Kane· @graokane · X·· 21 hours agoScore70

paclitaxel

Body

Paclitaxel +\-tovecimig: COMPANION-002 ph2/3
➡️prev treated #BTC wo actionable alterations
➡️ORR 17.1 v5.3%; DCR 62 v 37%
➡️mPFS 4.7 v 2.6mths - benefits seen at PFS2 noting crossover
➡️OS not sig but nb crossover
@myESMO #ESMO26 @OncoAlert

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Conference abstracts
2878ROmatched by Rapid oral 1: Gastrointestinal tumour, upper digestive

FOLFIRI plus ramucirumab versus paclitaxel plus ramucirumab as second-line therapy for taxane-pretreated patients with advanced or metastatic gastroesophageal adenocarcinoma–Final results of the phase III IKFs602/AIO RAMIRIS Study

https://esmocongress.esmo.org
543ROmatched by Rapid oral: Breast cancer, early stage

DESTINY-Breast11: MRI-assessed objective responses during neoadjuvant treatment (NAT) with trastuzumab deruxtecan (T-DXd) followed by paclitaxel + trastuzumab + pertuzumab (THP) vs dose-dense doxorubicin + cyclophosphamide followed by THP (

https://esmocongress.esmo.org
LBA37matched by Proffered paper: Gynaecological cancers

Durvalumab (D) plus carboplatin/paclitaxel (CP) followed by D with or without olaparib (O) in advanced/recurrent endometrial cancer (a/rEC): Interim overall survival (OS) and safety from the randomised phase 3 DUO-E/GOG-3041/ENGOT-EN10 stud

https://esmocongress.esmo.org

Source: Grainne O'Kane · x.com

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