mp.weixin.qq.com· 佛山综合细胞库·· 4 hours agoPickScore73
Mesenchymal Stem Cell Randomized Trial Shows 63.4-Meter Greater 6-Minute Walk Improvement in Older Frail Adults Versus Placebo
博士视界 | 给衰老的身子“充个电”：——随机试验显示间充质干细胞改善老年虚弱者步行能力
In brief
A randomized Phase IIb trial showed that after a single intravenous infusion of mesenchymal stem cells, the 200-million-cell dose group improved 6-minute walk distance by 63.4 meters more than placebo at 9 months (p=0.0077). The double-blind, placebo-controlled dose-escalation study (NCT03169231, N=148) showed dose- and time-dependent improvement in walk distance. Blood soluble TIE-2 declined with dose, suggesting a potential efficacy marker.
Why it matters
The brief gives the 200-million-cell group versus placebo 6-minute walk results with p-value, enabling comparison of cell dose with walking improvement.
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