Yakup Ergün· @dr_yakupergun · X·· 2 days agoScore90
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#ESMO26 | HORIZON-Breast06
Impressive PFS benefit✨️
In HER2-low mBC, trastuzumab rezetecan significantly improved PFS vs chemo:
16.4 vs 6.8 mo
Benefit was consistent in HR+ (HR 0.24) and HR− (0.34) pts
OS remains immature, but an encouraging trend is emerging (HR 0.67).
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Conference abstracts
LBA13matched by Proffered paper 1: Breast cancer, early and advanced stage
Trastuzumab rezetecan (SHR-A1811) in HER2-low advanced breast cancer (BC): A randomized, phase 3 study (HORIZON-Breast06)
https://esmocongress.esmo.org#ESMO26 | HORIZON-Breast06 HER2-low mBC after ≥1 prior line of chemo for metastatic disease, or in the first-line chemo setting after prior ET (if HR+). Trastuzumab rezetecan vs. physician’s choice of chemo PFS: 16.4 vs 6.8 mo (HR 0.27) ORR: 75.5% vs 41.2% Grade ≥3 TRAEs: 84.1% vs 67.9% ILD: 2.5%.在 X 查看被引用的帖子
Source: Yakup Ergün · x.com