#ESMO26 Dr. David Sommerhalder presents OS from M21-404: telisotuzumab adizutecan (Temab-A), a c-MET directed ADC with a topo-1 payload. mPFS 6.8m OS 13.8m in EGFR wild type. mPFS

Stephen V Liu, MD· @StephenVLiu · X·2026-10-24 15:45· 23 hours agoScore70

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#ESMO26 Dr. David Sommerhalder presents OS from M21-404: telisotuzumab adizutecan (Temab-A), a c-MET directed ADC with a topo-1 payload. mPFS 6.8m OS 13.8m in EGFR wild type. mPFS 10.9m OS 16.2m in EGFR mutant. cMET expression predicts outcomes in EGFRwt, not so in EGFRmt.

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Conference abstracts

2658ROmatched by Rapid oral 1: NSCLC, metastatic

Overall survival (OS) analysis of telisotuzumab adizutecan in patients (pts) with nonsquamous non-small cell lung cancer (NSQ NSCLC): Phase 1 first-in-human study

https://esmocongress.esmo.org

791ROmatched by Rapid oral: Gastrointestinal tumours, lower digestive

Long-term follow-up of telisotuzumab adizutecan (ABBV-400, Temab-A) in combination with bevacizumab (Bev) vs standard of care (SOC) in patients (pts) with 3L+ colorectal cancer (CRC): Updated results of a phase 1 study

https://esmocongress.esmo.org

Source: Stephen V Liu, MD · x.com