Efficacy and safety of Lianhua Qingwen versus oseltamivir in children with influenza: a multicenter, randomized, double-blind, positive parallel-controlled study

A multicenter randomized double-blind trial found Lianhua Qingwen non-inferior to oseltamivir for clinical recovery time in children aged 3-14 years with influenza. A total of 520 participants were randomized, 260 per group. Median clinical recovery time was 5 days in both groups, with clinical recovery rates of 71.5% versus 71.2% (HR 1.04, 95% CI 0.84-1.29, one-sided p 0.05).