Nature· Fan Yu·· 19 hours agoPickScore71
GRP75-dependent SIMPA mediates inter-organellar quality control
In brief
Under proteotoxic stress, GRP75-dependent protein aggregates signal through mitochondria-ER contact sites, activating a selective quality-control pathway with SIMPA as a key node that clears damaged proteins and preserves mitochondrial integrity. DOI: 10.1038/s41586-026-10733-y.
Why it matters
The study anchors protein aggregate signaling to GRP75- and SIMPA-dependent mitochondria-ER contact sites, providing a testable molecular module for inter-organellar quality control.
Source: Nature