bioRxiv· Bass, A. J., Park, J., Mukherjee, S., Whittaker, J., Wallace, C. ·· 1 day agoPickScore47
Genomic foundation models do not yet boost common variant discovery beyond standard functional annotations
In brief
A study compared three genomic foundation models, AlphaGenome, Borzoi and GPN-Star, against the standard baselineLD functional annotation for common variant discovery across 27 UK Biobank traits. It found that GFMs have not yet surpassed standard functional annotations.
Why it matters
Reports a benchmark comparing genomic foundation models with standard annotations.
Source: bioRxiv