🔴 Live from #ESMO2026
New results from the phase 2 FOURLIGHT-1 study show promising activity with atirmociclib + fulvestrant in patients with HR+/HER2− metastatic breast cancer who had progressed on prior CDK4/6 inhibitor therapy.
📊 Key findings:
PFS: 9.4 vs 6.6 months (HR 0.60; P=0.0007)
ORR: 19.3% vs 11.3%
DOR: 14.8 vs 9.3 months
CBR: 61.9% vs 46.0%
OS: data not yet mature
The results support further evaluation of selective CDK4 inhibition, including in earlier treatment lines.
https://www.annalsofoncology.org/article/S0923-7534%2826%2908074-9/fulltext
#ESMO26 #BreastCancer #mBC #Oncology
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Efficacy and safety of atirmociclib (ATI) + fulvestrant (FUL) in patients (pts) with HR+/HER2– advanced/metastatic breast cancer (mBC) who progressed on prior CDK4/6 inhibitor (CDK4/6i) in a randomized phase 2 study (FOURLIGHT-1)
https://esmocongress.esmo.orgFOURLIGHT-1
https://esmocongress.esmo.orgSource: Mirrors of Medicine · x.com