Nature· Hyun Ju Lee·· 19 hours agoPickScore86
Cold activates a BH2 metabolic network promoting longevity and proteostasis
In brief
In C. elegans, cold drives BH2 synthesis in muscle via CAT-4; BH2 is reduced to BH4 in distal tissues, where PAH-1 uses it to synthesize tyrosine, extending lifespan and improving cross-tissue proteostasis. BH2 or tyrosine supplementation likewise suppresses aggregation of toxic proteins including polyQ74, TDP-43(A382T) and FUS(P525L) in HEK293 cells and ALS iPS-derived motor neurons.
Why it matters
The study shows cold extends lifespan and improves proteostasis via muscle BH2 synthesis and intertissue transport in worms and human cells, partly without cold.
Source: Nature