bioRxiv Cancer Biology· Shu, Q., Wu, J., Wang, Z., Cheng, Y., Liang, X., Li, Y., Tao, H., Shi, H., Peng, Y., Qin, B., Zou, B., Xu, F., Wang, J., Nie, Y., Shi, Y., Fan, D., Liu, N., Li, L., Wen, T., Xie, N. ·· 23 hours agoPickScore68
Matrix stiffness shapes immunometabolic states and response to PD-1 blockade in gastric cancer
In brief
High matrix stiffness in gastric cancer is associated with collagen deposition, immune exclusion, and poorer response to PD-1 blockade, and it weakens CD8+ T cell effector function through F-actin remodeling, YAP nuclear enrichment, and LDHA-dependent glycolysis.
Why it matters
Links clinical cohort correlations with F-actin, YAP, and LDHA mechanism experiments to show how matrix stiffness affects PD-1 blockade response in gastric cancer.
Source: bioRxiv Cancer Biology · biorxiv.org