The #OncoAlertTopTweet 🚨 #ESMO26 DAY 2
Post by @ProfGLongMIA
🚨 INTerpath-001 at #ESMO26: adding #intismeran autogene, an individualized mRNA neoantigen therapy, to pembrolizumab cut the risk of recurrence or death by 42% in high-risk resected #Melanoma. A first phase 3 win for personalized cancer vaccines 👇 #OncoAlert
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INTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
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https://esmocongress.esmo.orgIt was a great honour to present the results of the phase 3 INTerpath-001 clinical trial at the #ESMO26 Congress in Madrid. This international trial included 1137 patients, across 157 sites, whose melanoma had been surgically removed, but who were at very high risk of it returning. The trial showed adding #intismeran autogene, an mRNA based individualised neoantigen therapy, to pembrolizumab reduced the risk of recurrence or death by 42%. This is the first phase 3 study to show that a treatment built from the unique ‘fingerprint’ of a patient’s own tumour can reduce the risk of recurrence or death from cancer. That fingerprint is read by sequencing the tumour, then a ‘wanted poster’ of the cancer is made as mRNA, showing the immune system exactly what to look for and attack. Having succeeded in melanoma, this proof of concept could mark the beginning of a foundational shift in how we treat cancer. Read more >https://melanoma.org.au/news/personalised-cancer-vaccine-cuts-risk-of-melanoma-recurrence/ A huge thank you to all patients and teams involved. @myESMO @Sydney_Uni @syd_health @Science_Academy @AAHMS_health @FulbrightAUS @NthSydHealth @ausoftheyear在 X 查看被引用的帖子
Source: OncoAlert · x.com