Can liquid biopsy replace tumour tissue in mCRPC?

Deborah Mukherji· @dmukherji · X·2026-10-23 20:20· 2 days agoScore70

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PROMPT study at #ESMO26: ctDNA detected 82% of HRR-altered cases, adding 7% yield to tissue testing.

But PI3K/AKT alterations, particularly PTEN biallelic losses, were frequently missed @MehraNiven @OncoAlert

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Conference abstracts

2220RONCT04746300matched by Rapid oral: Genitourinary tumours, prostate, penile and testis

Plasma ctDNA as standalone or adjunct to tumour tissue for HRR and PI3K/AKT genotyping in mCRPC: PROMPT (NCT04746300)

Source: Deborah Mukherji · x.com