Nanotherapy targets senescent cells

A study by Hinterleitner et al., published in Science in 2026, shows that a senescent-cell-targeted nanotherapy can ameliorate fibrosis in cancer and overcome immune exclusion (DOI: 10.1126/science.aeg4791). Cellular senescence can support tissue repair and suppress carcinogenesis, but its persistence drives chronic inflammation, fibrosis and immune dysfunction. Drugs targeting senescent cells have shown promise in preclinical models, but toxicity has limited translation.