Nature·· 4 hours agoPickScore84
GRP75-dependent SIMPA mediates inter-organellar quality control.
In brief
Research shows that a GRP75-dependent SIMPA signalling pathway mediates quality control between mitochondria and the endoplasmic reticulum. Under proteostatic stress, damaged mitochondrial proteins are sequestered to form stress-induced mitochondrial protein aggregates (SIMPAs). Quantitative proteomics and correlative light-electron microscopy show that SIMPA activates the ER unfolded protein response in a spatially confined manner at mitochondria-ER contact sites or mitochondria-associated membranes to clear aggregates.
Why it matters
Quantitative proteomics and correlative light-electron microscopy localize SIMPA to mitochondria-ER contact sites, revealing a cross-organellar quality control mechanism.
Source: Nature · doi.org