Mali Barbi, MD MSc | Breast & Gyn Oncologist· @DrBarbiOnc · X·· 2026-04-21Score60
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Next-generation ADCs: payload innovation
T-DXd is already rewriting the first-line standard.
Body
#AACR26 | ADC + #PARPi - finally a rational approach
Phase 1 of T-DXd + olaparib in HER2-expressing gynecologic cancers. 28 pts - 16 ovarian, 12 endometrial (mostly uterine serous). Median 3.5 prior lines. Mostly BRCA wildtype, 37.5% HRD negative.
The concept is smart: #topo1i +
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Conference abstracts
Elizabeth K. Lee, Andrea Wahner Hendrickson, Gerardo Colon-Otero, Cheryl A. Pickett, Yinglu Zhou, Su-Chun Cheng, Madeline Polak, Hannah Sawyer, Martin Hayes, Ursula A. Matulonis, Geoffrey I. Shapiro, Panagiotis A. Konstantinopoulos
Read the abstract →Source: Mali Barbi, MD MSc | Breast & Gyn Oncologist · x.com