Paul H, PharmD, RPH· @phsiao4 · X·· 14 hours agoScore70
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DeLLphi-305 (phase III) #ESMO26.
Tarlatamab + durvalumab vs durvalumab alone, 1L maintenance ES-SCLC. Median OS 21.1 vs 12.7 months, HR 0.42, 58% reduction in risk of death. https://x.com/nejm/status/2114003233664282879?s=46
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Conference abstracts
LBA3matched by Presidential Symposium I
Tarlatamab plus durvalumab (durva) vs durva as 1L maintenance (1LM) therapy following durva, platinum, and etoposide (1L durva + EP) in extensive-stage small cell lung cancer (ES-SCLC): Primary analysis of the phase 3 DeLLphi-305 trial
https://esmocongress.esmo.org‼️ Impressive results from DeLLphi-305 (phase III) just out this afternoon #ESMO26. Tarlatamab + durvalumab vs durvalumab alone, 1L maintenance ES-SCLC. Median OS 21.1 vs 12.7 months, HR 0.42, 58% reduction in risk of death. This is great news for people affected by small cell #lungcancer. Both drugs already have EU and UK approvals on their own. The real gap: new medicines can still take 600+ days to reach patients in lower-income European countries. Practice-changing data is only half the story. https://lungcancereurope.eu/news/tarlatamab-durvalumab-dellphi-305-sclc-survival #LCSM在 X 查看被引用的帖子
Source: Paul H, PharmD, RPH · x.com