CheckMate 8HW final OS at #ESMO26: NIVO+IPI in centrally confirmed MSI-H/dMMR mCRC

▪️ All lines vs NIVO: HR 0.61 (0.46–0.82), p=0.0009; 5-yr OS 74% vs 62%
▪️ 1L vs NIVO: HR 0.66 (0.44–0.99), p=0.043, missed prespecified boundary (p<0.0058); 5-yr OS 77% vs 66%
▪️ 1L vs chemo: OS HR 0.37, p<0.0001
▪️ Median f/u ~68 mo; safety stable, low grade 3/4

#CRCSM #MSIH