⏫ Early-onset #ColorectalCancer incidence is rising. The gut microbiome may have answers.

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AACR 2026 现场信号· @ · X·2026-04-22 03:41· 2026-04-22Score60

#COLORECTALCANCER

Reading

KRAS / RAS 靶向 — 从平台化到 Ph3 验证

Deep dive

发生了什么

City of Hope的GI肿瘤医学总监Pashtoon Kasi将在AACR26会议上展示Clover试验的突破性发现，地点为Section 41、Poster 14，时间为下午2点至5点。

为什么重要

据报道该试验为II期研究^[1]，聚焦微卫星稳定型结直肠癌^[2]，并涉及一种靶向CCR5的Lironi MAP分子^[3]，这些数据可能为难治性结直肠癌提供新的治疗思路。

还缺什么

完整的疗效数据、安全性概况及生物标志物分析尚未公开，待会议墙报发布后进一步解读；后续需关注该试验是否推进至III期注册研究及监管沟通进展，目前均待确认。

References

1.Highlights from AACR 2026 Part 3 · oncodaily.com 2026
2.Pashtoon Kasi MD, MS · x.com 2026
3.#aacr26 #colorectalcancer | Pashtoon Kasi · linkedin.com 2026

Body · original

⏫ Early-onset #ColorectalCancer incidence is rising. The gut microbiome may have answers.

@Enrique_VelVi @cityofhope discussed “distinct” differences in early-onset disease and how #AI found heterogeneity based on genetics and environment. @AACR #AACR26 https://t.co/oE8P1bembE

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Source: AACR 2026 现场信号 · x.com