biorxiv.org· Cabrera-Cosme, L., Rubio-Lara, J. A., Bennett, E., Miłek, J., Baldreki, C., Dowle, A., Vijayabaskar, M. S., Davies, S. J., Taylor-Smith, E., Bain, F. M., MacDonald, S., James, S., Hogg, K., Jassinskaja, M., Gottgens, B., Wilson, N. K., Kent, D. G. ·· 16 hours agoPickScore66
A scalable in vitro cell competition model identifies preleukemic super competitor clones
A scalable in vitro cell competition model identifies preleukemic super competitor clones
In brief
A team has developed a scalable in vitro clonal competition platform, described in a bioRxiv preprint, and found that ~10% of TET2-mutant clones actively and selectively suppress WT cell expansion. In some cases these clones completely eliminate WT clones, and molecular analysis and functional assays point to inhibition of RAC1-GEF signalling as a WT-cell-specific vulnerability. DOI: https://doi.org/10.64898/2026.10.21.760611
Why it matters
The platform lets single-cell-derived clones be split and cross-competed against multiple opposing-genotype clones in parallel, enabling large-scale study of cell competition dynamics.
Source: biorxiv.org · biorxiv.org