KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
$RVMD Cowen RVMD (Buy) - Revved Up for PDAC Domination #AACR26 RVMD presented further support for daraxonrasib's 1L use as both mono and in chemo combo. The 6mo PFS rates for mono/combo of 71/84% and 6mo OS of 83/90% track well above SoC chemo and we expect the gap to continue widening with more maturity given the RASolute302 OS outcome. updated model to include darax peak U.S. PDAC sales of $9B
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