Cell·· 5 hours agoPickScore82
Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade.
In brief
A Cell original study establishes the lifestyle-induced susceptibility to irAEs (LISA) model, in which a high-fat diet drives metabolic and microbial alterations that recreate human-like multi-organ toxicity from anti-PD-1 therapy.
Why it matters
The LISA model reproduces susceptibility to human immunotherapy toxicity, reveals Akkermansia-driven Treg fragility, and shows dietary and metabolic interventions restore Treg stability.
Source: Cell · doi.org