Nature Genetics· S. Taylor Head·· 15 hours agoPickScore66
Quantification method affects replicability of eQTL analysis, colocalization and TWAS
In brief
A methodological study of eQTL analysis shows that transcript annotation and quantification methods in upstream RNA-seq processing can affect eQTL mapping, TWAS, and colocalization with GWAS results.
Why it matters
Shows how transcript annotation and quantification choices change eQTL mapping, colocalization and TWAS, providing checkpoints for verification and replication.
Source: Nature Genetics · nature.com