bioRxiv· Liu, H., Mao, S., Gallent, T., Chen, Y., Yan, Z., Vogel, I., Traunmuller, L., Zhang, R., Buenrostro, J. D., Zhou, J., Greenberg, M. E. ·· 13 hours agoPickScore58
Predicting cell-state-specific gene regulation from DNA across species
In brief
Bolero is a sequence-to-function deep learning model whose parameters are conditioned on atlas-scale cell-state embeddings and additional biological variables, predicting cell-state-specific chromatin accessibility and transcript abundance from DNA.
Why it matters
Bolero couples cell-state embeddings with a DNA sequence model, tracing non-coding variant effects to specific cell types and extending comparative genomics from sequence conservation to predicted functional conservation.
Source: bioRxiv