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mp.weixin.qq.com·· 8 hours agoPickScore85

Zhongsheng's RAY1225 Hits Primary Endpoint in Phase 3 REBUILDING-2, 9 mg Group Loses 22.24% Body Weight

In brief

Zhongsheng Pharmaceutical's RAY1225 (beiporpotide) met the primary endpoint in the Phase 3 REBUILDING-2 study in overweight or obesity, with the 9 mg group losing 22.24% of body weight from baseline over 52 weeks. Placebo-adjusted weight loss was 20.46% (P<0.0001), with the 3 mg and 6 mg groups at 11.23% and 17.42%, respectively; in the 9 mg group, 99.3%, 82.1% and 53.8% achieved weight loss of at least 5%, 15% and 20%.

Why it matters

The article places RAY1225 alongside 52-week tirzepatide data while noting cross-trial limits from population, dose titration and dosing interval, supporting a cautious read of its differentiated value.

Source: mp.weixin.qq.com · mp.weixin.qq.com

CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org