KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
🚀 Big news from #AACR26!
@RevMedicines RM-055: “RAS GAP on steroids” 🔥
Catalytic RAS(ON) inhibitor supercharges GTP hydrolysis, drives deep tumor regressions in G12 mutant PDAC/NSCLC/CRC models & overcomes daraxonrasib resistance 👏
#OncTwitter #gism #MedTwitter #MedX @AACR
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