cell.com· Dipyaman Patra, Katelyn Wolfgang, Chenxian Ye, Lora Rigatti, Kelsey Ertwine, Kristin M. Morder, Jessica Jana, Ishita Baral, Drew Hurd, Kaitlin Bossong, Steven Mullett, Yingtong Dou, Stacy Gelhaus, Dario A.A. Vignali, Diwakar Davar, Anthony R. Cillo, Greg M. Delgoffe, Abigail E. Overacre-Delgoffe·· 19 hours agoPickScore75
Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade
In brief
Dietary and microbial alterations can increase susceptibility to irAEs after immune checkpoint blockade by promoting IFN-γ-driven Treg fragility and cytotoxic tissue-resident T cell responses. Disrupting IFN-γ signaling specifically in Tregs restores tissue homeostasis and reduces irAEs without compromising antitumor immunity, suggesting Treg stability is a potential therapeutic strategy for limiting checkpoint blockade toxicity.
Why it matters
Links lifestyle-related Treg fragility to irAEs and suggests targeting IFN-γ signaling to reduce adverse events while preserving antitumor immunity.
Source: cell.com · cell.com