#ESMO26 🧬 TOMAS2 | Advanced STS

🔬 PARP1 H-score as predictive biomarker for trabectedin + olaparib.

🎯 H-score ≥70:

📈 All STS: mPFS 4.3 vs 2.5 mo
HR 0.49; p=0.008

📈 Uterine LMS: mPFS 16.3 vs 1.35 mo
HR 0.15; p=0.009

❌ No benefit with H-score <70.

🚀 PARP1 emerges as a promising predictive biomarker. External validation needed!

@OncoAlert