nature.com·· 16 hours agoPickScore67
Human Argonaute 2 is a programmable targeting domain for RNA editing
Human Argonaute 2 is a programmable targeting domain for RNA editing
In brief
ALTER is a programmable RNA base editor built entirely from human proteins, using human AGO2 in place of bacterial CRISPR–Cas proteins as its targeting domain. The design reduces a key risk of harmful immune responses in therapeutic applications and is generally more effective than dCas13-based editors.
Why it matters
ALTER replaces bacterial CRISPR–Cas proteins with human AGO2, lowering harmful immune response risk and outperforming dCas13-based editors overall.
Source: nature.com · nature.com