GLP1s for Migraines: Side Effects Around Nervous System / Abdominal Migraines?

In a r/migraine post, u/Fine_Twist371, who has chronic inflammation-driven migraines, switched to a GLP-1 after a year of trying medications, for two purposes: to leverage its anti-inflammatory side effect and to use its suppression of food cravings (the poster is overweight but weight loss is not the goal). Comment section feedback was mixed: u/GrumpyHeadmistress reported that after titrating up tirzepatide, slowed gastrointestinal transit delayed absorption of migraine medications, leading to recurrence of daily migraines; u/Prada_baby said their frequency went from chronic to episodic, which was 'nothing short of a miracle,' but heartburn was severe; u/stormblessed579, u/MyCatSaidNotTo and others discussed acid reflux, constipation, and other gastrointestinal side effects and their mechanistic connection to GLP-1s. On the factual level, delayed gastric emptying from GLP-1s is an established pharmacological effect, while the relationship between their neural/anti-inflammatory effects and migraine remains at the stage of anecdote and hypothesis. At the speculative level, all narratives of 'GLP-1 improving or worsening migraines' are individual experiences, with no controlled studies supporting causation.

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