Cell· Jun W. Kim, Christina M. Bebber, Yuqin Dai, Sarah Bopp, Anna Edenhofer, Albert M. Li, Thomas Rösner, Lena Berning, Ming Yang, Logan B. Leak, Jenny Stroh, Bindesh Shrestha, Ali T. Abdallah, Dimitrios Prymidis, Hernando J. Olivos, Maya Baron, Thuyen Nguyen, Yan Ting Shue, Yoko Nishiga, Alexandros P. Drainas, Andrea C. Chaikovsky, Krystina Szylo, Yang Li, Yun P. Kang, Parvathy Manoj, Alvaro Quintanal Villalonga, Charles M. Rudin, Gina M. DeNicola, Scott J. Dixon, Christian Frezza, Jiangbin Ye, Silvia von Karstedt, Julien Sage·· 19 hours agoPickScore70
Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer
In brief
Distinct cell states in small cell lung cancer correspond to specific metabolic networks that determine whether cells undergo ferroptosis or apoptosis under metabolic stress. The finding links cell-state differences to metabolic plasticity, providing mechanistic context for how these two death fates arise.
Why it matters
Compares how different SCLC cell states diverge toward ferroptosis or apoptosis under metabolic stress, offering a mechanistic framework for their metabolic plasticity.
Source: Cell · cell.com