Cell· Llywelyn Griffith, Charlotte Capitanchik, Shaun Moore, Anca Farcas, Mags Gwynne, Martina Pedna, Ivana Vukšinić, Veronika Bračič, Karen Davey, D. Marc Jones, Anob M. Chakrabarti, Dimitris Lagos, Jelena Urosevic, James T. Lynch, Jernej Ule·· 19 hours agoPickScore62
Protein arginine methylation promotes global 3′UTR shortening in proliferating cells
In brief
Griffith et al. report in Molecular Cell that protein arginine methylation drives production of short mRNA isoforms in rapidly dividing cells by promoting PCF11 assembly into the cleavage and polyadenylation machinery. PRMT inhibitors broadly lengthen 3′UTRs in cancer cells, organoids, and T cells, indicating a targetable link between methylation and alternative polyadenylation.
Why it matters
PRMT inhibition broadly lengthens 3′UTRs in cancer cells, organoids, and T cells, supporting a strategy to target alternative polyadenylation.
Source: Cell