medicalxpress.com· Medical Xpress - Cancer·· 21 hours agoPickScore66
Glioblastoma's secret weapon: Silencing the brain's off switch
In brief
A Baylor College of Medicine team found in animal models that glioblastoma weakens GABA-mediated inhibition of brain circuits through GAT-1 and DBI, driving circuit hyperexcitability and tumor growth. Removing GAT-1 accelerated tumor growth, activating inhibitory neurons near the tumor slowed growth, and blocking those neurons further promoted growth.
Why it matters
The report lays out animal-model evidence linking GAT-1, DBI and GABA signaling to glioblastoma growth and compares neuronal activation with drug intervention.
Source: medicalxpress.com · medicalxpress.com