bioRxiv Genomics· Vyas, H. S., Leix, K., Burugula, B. B., Paye, S. M., Raut, C., Speliotes, E. K., Emmer, B. T. ·· 17 hours agoPickScore63
Multimodal functional characterization of the LDLR noncoding landscape
In brief
Researchers used saturation CRISPR nuclease screening, CRISPR activation and inhibition screens, and a massively parallel reporter assay to systematically characterize noncoding cis-regulatory regions at the LDLR locus. Each method identified previously unrecognized regions affecting LDLR expression, but the CRE sets overlapped without being identical and also differed from computational predictions. DOI: 10.64898/2026.10.22.761041.
Why it matters
Multiple functional genomics methods each found previously unrecognized LDLR regulatory regions, with overlapping but distinct hit patterns.
Source: bioRxiv Genomics · biorxiv.org