QTX3034 + cetuximab ± mFOLFOX6 in KRAS G12D mCRC: preliminary results

Evelyn Wong· @EvelynWongYT · X·2026-10-24 21:28· 17 hours agoScore70

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QTX3034 + cetuximab ± mFOLFOX6 in KRAS G12D mCRC: preliminary results
👉 ORR: 25% vs 50%
👉 DCR: 75% vs 90%
Encouraging signal for adding chemotherapy. small cohorts; durability & comparative data needed!
#ESMO26 #ESMOAmbassadors @OncoAlert

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Conference abstracts

788ROmatched by Rapid oral: Gastrointestinal tumours, lower digestive

Encorafenib plus cetuximab (EC) beyond progression in combination with FOLFIRI in BRAF V600E metastatic colorectal cancer (mCRC) patients (pts) progressing on EC: Results from the ECLYPse phase II trial

https://esmocongress.esmo.org

NCT06578559NCT06578559matched by - **标题 / Title：** Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC

- **标题 / Title：** Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC

https://esmocongress.esmo.org

NCT06640166NCT06640166matched by - **标题 / Title：** Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.

- **标题 / Title：** Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.

https://esmocongress.esmo.org

Source: Evelyn Wong · x.com