bioRxiv Cancer Biology· Guleria, S., Liyanage, C. D., Hutchison, W. J., Treller, K., Neil, L., Gao, Y., Yeo, B., Mariadason, J. M., Kallies, A., Kearney, C. J., Mielke, L. A., Vodala, S., Anderson, R. L., Merino, D., Papenfuss, A. T., Yadav, V. K., Vasanthakumar, A., Mangiola, S., Pal, B. ·· 17 hours agoScore62
ICOS blockade alleviates immune suppression in breast tumor microenvironment
In brief
Researchers found that ICOS blockade disrupts the Treg immunosuppressive niche in triple-negative breast cancer, and in syngeneic orthotopic models restricts primary tumor growth, reduces spontaneous metastasis and prolongs survival.
Source: bioRxiv Cancer Biology · biorxiv.org