medicalxpress.com· Medical Xpress - Cancer·· 19 hours agoPickScore69
'Molecular glue' stabilizes protein that inhibits development of non–small cell lung cancer and uterine cancer
In brief
In two peer-reviewed studies, a University of Michigan team showed that the PP2A molecular glue RPT04402 stabilizes the PP2A complex and suppresses growth of KRAS-mutant non–small cell lung cancer and high-grade uterine cancer in models.
Why it matters
Cell experiments showed adagrasib or trametinib destabilize PP2A; RPT04402 restored complex stability, delayed resistance in combination-treated mice, and showed tumor suppression in lung and uterine cancer models.
Source: medicalxpress.com · medicalxpress.com