Molecular Cell· Ashish Verma, Changlei Zhu, Bernadette Truong, Silvija Bilokapic, Rebekah DeVries, Aaron Pitre, Younus A. Bhat, Anang A. Shelat, Mario Halic, Hai T. Dao·· 19 hours agoPickScore70
PARP1 directly disassembles nucleosomes to regulate DNA repair
In brief
PARP1 directly disassembles nucleosomes, promoting NAD+-dependent removal of H2A-H2B dimers and generating oriented hexasomes with higher DNA accessibility. The H2A C-terminal tail supports this remodeling activity, linking PARP1-dependent nucleosome disassembly to the cellular response to DNA damage.
Why it matters
It shows how PARP1 promotes H2A-H2B dimer eviction and hexasome formation, connecting nucleosome disassembly to the DNA damage response.
Source: Molecular Cell · cell.com