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Cell Study Finds cMAF Loss in Perivascular Macrophages Causes Blood-Brain Barrier Leakage
In brief
A 2026 Cell study found that deleting cMAF in perivascular macrorophages (PVMs) causes immediate blood-brain barrier leakage. The pathway is conserved between humans and mice, and the article accordingly treats PVMs as the macrophage-lineage platform for the next round of cell therapy competition in neurological disease.
Why it matters
Because cMAF deletion causes barrier leakage, the work adds macrophages to blood-brain barrier repair mechanisms and shifts focus from endothelial cells and astrocytes to perivascular macrophages.
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