bioRxiv· Sung, J.-Y., Cheong, J.-H. ·· 21 hours agoPickScore70
Delocalized DNA holes imprint mutation position in mismatch-repair-deficient cancers
In brief
In mismatch repair deficient gastric, colorectal and endometrial cancers, researchers found G>T mutations within guanine runs enriched at the 5' guanine (0.86~0.87) and depleted at the 3' guanine (0.05~0.08).
Why it matters
The study links mutation position within guanine runs to delocalized hole charge density, showing a fit-free match across four datasets and consistency across cancer types.
Source: bioRxiv