Raffaele Colombo· @raffcolo · X·· 16 hours agoScore70
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OptiTROP-Lung06: Sac-TMT + pembro vs chemo + pembro in NSQ NSCLC.
PFS correlation (?) with TROP2 expression from the concomitant @NEJM publication (in the appendix).
#ESMO26
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Conference abstracts
2631ROmatched by Rapid oral 1: NSCLC, metastatic
First-line BAT8008 (TROP2-ADC) plus BAT1308 (anti-PD-1) for advanced NSCLC: Results from a multicenter phase 2 study
https://esmocongress.esmo.org#ESMO26 Dr. Caicun Zhou presents OptiTROP-Lung06: 1L Sac-TMT (TROP2 ADC) + pembro vs chemo + pembro in non-squamous NSCLC. PFS 15m vs 5.7m (HR 0.49). OS immature but 1y rate 78% vs 66% (HR 0.58). mDOR 13.6m vs 6.8m. TEAEs leading to d/c of drug 6% with Sac-TMT 14% with chemoIO.在 X 查看被引用的帖子
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- Raffaele Colombo@raffcolo
@NEJM "The data showed a consistent treatment effect irrespective of the level of Trop-2 expression" Overlap of the 3 KM curves 👇
Source: Raffaele Colombo · x.com