#ESMO26 | 2894P Retrospective study of 1L Tx for ESCC with supraclavicular lymph node metastasis Chemo + ICI (CI) vs CRT (CCRT) vs Chemo + ICI followed by RT (CIRT) ▪️3y-OS: 52.1% vs 70.8% vs 69.8% ▪️Superior PFS in CIRT vs CI (adjusted HR 0.73), OS (HR 0.48) ▪️Superior PFS in CIRT vs CCRT (HR 0.67) 👉Clinically meaningful analysis, although potential selection and immortal time biases should be considered, as patients with early progression on chemo + ICI may not have entered the CIRT group. @myESMO @OncoAlert