The Innovation | Medicine· @Innov_Medicine · X·· 2026-04-19Score60
Reading
KRAS / RAS targeting: from platform to Phase 3
First-generation G12C drugs (sotorasib, adagrasib) bind KRAS in the off state.
Body
#AACR26
@AACR
· The KRAS story is reorganizing.
Reading
@HartungIngo
(Day 1 highlight) +
@DrMirallas
(Ambrogio live capture) together — Day 1 KRAS signals seem to organize around three paths:
1/ ON + OFF together
Sotorasib/adagrasib lock the OFF (GDP-bound) state. Resistance
Heat 8 · 6 likes · 1 reply · 1 repost
Source: The Innovation | Medicine · x.com