Science· Alvaro Murillo, Melanie Alpaugh, Ruban Rex Peter Durairaj, Emma L. Randall, Meghan Larin, Laura Heraty, Alys N. Aston, Alysha S. Taylor, Alex Mas Monteys, Nina Stöberl, Aeverie E. R. Heuchan, Pascale Aeschlimann, Kyle Fears, Christian Landles, Georgina F. Osborne, Antoine Mangin, Soumyasree Bhattacharyya, Emmanouil Metzakopian, Nicholas D. Allen, Jack Puymirat, Gillian P. Bates, Beverly L. Davidson, Francesca Cicchetti, Mariah J. Lelos, Vincent Dion·· 17 hours agoScore61
Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington’s disease mouse model
In brief
Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model. The article appears in Science Translational Medicine, Volume 18, Issue 872 (October 2026); the current material does not provide the full text, sample size, or specific effect sizes.
Source: Science