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mp.weixin.qq.com·· 10 hours agoScore67

Southwest Hospital Team Explains How IGF-1/SLC25A33 Downregulation Disrupts Blood-Labyrinth Barrier and Hearing in Aged Mice

In brief

Bai Yang's team at Southwest Hospital has elucidated how downregulation of the insulin-like growth factor 1/mitochondrial solute carrier 25A33 signaling axis disrupts the blood-labyrinth barrier and causes hearing loss in aged mice. Published in Aging Cell, the study found both molecules decreased in the stria vascularis of aged mice; reduced SLC25A33 led to mitochondrial ROS accumulation and TGF-beta/Smad2 pathway activation, driving abnormal pericyte differentiation and disrupting barrier tight junctions.

Source: mp.weixin.qq.com · mp.weixin.qq.com

#Primary research#Neuroscience
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