nature.com· Peter A. Gerlach·· 16 hours agoPickScore64
High false sign rates in transcriptome-wide association studies
High false sign rates in transcriptome-wide association studies
In brief
An article by Peter A. Gerlach in Nature Genetics finds that the direction of effect captured by transcriptome-wide association studies is often reversed relative to the true biological mechanism. Published online on 22 October 2026, the article calls for caution when interpreting such studies and applying their results downstream.
Why it matters
The finding that effect directions in transcriptome-wide association studies can be reversed informs interpretation and downstream use.
Source: nature.com · nature.com