mp.weixin.qq.com·· 12 hours agoPickScore78
Nature Biotechnology study engineers CAR-NK cells in vivo with ligand-directed LNPs
In brief
A Nature Biotechnology paper reports that an MIT team built targeted LNPs carrying NK receptor ligands, termed NtLNPs, achieving efficient NK cell transfection in mice and in vivo engineering of CAR-NK cells. The strategy was evaluated for therapeutic potential in B cell depletion, autoimmune hepatitis, solid tumor, and humanized hematologic tumor models.
Why it matters
Ligand-directed LNPs targeting NK receptors achieved efficient in vivo NK cell transfection in mice, with therapeutic potential assessed in B cell depletion, autoimmune hepatitis, and tumor models.
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