KRAS / RAS targeting: from platform to Phase 3
The floor also showed dual ON/OFF (VS-7375) and RM-055, built for amplification and daraxonrasib-resistant models.
The floor rewrote the question from “how long can G12C monotherapy last” to “who first makes first-line pancreatic cancer a standard.” daraxonrasib’s Phase 3 is still the only RAS-inhibitor overall-survival win.
#AACR26
@AACR
· Daraxonrasib just moved from "promising" to "new standard of care" territory
Reading
@dr_yakupergun
's 1L mPDAC numbers alongside public disclosures by @RevolutionMeds in the days before #AACR26 opened, three data points organize the picture:
1/ Phase 3 RASolute
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Nina Dashti-Gibson, Amy L. Olex, Rachel K. Myrick, Alexa M. Barber, David C. Boyd, Emily K. Zboril, Katarzyna M. Tyc, Mikhail G. Dozmorov, Guang-Yu Yang, Nicholas T. Woods, Jose G. Trevino, J Chuck Harrell
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