cell.com· Shuke Xiao, Alan Sheng-Hwa Tung, Jan Spaas, Sipei Fu, Xudong Chen, Tuan Kiet Trinh, Maria Dolores Moya-Garzon, Veronica L. Li, Hannah T. Cessna, Kentaro Ito, Saranya C. Reghupaty, Chao Lin, Xuchao Lyu, Steffen H. Raun, Miles D.W. Tyner, Arthur Germakovski, Jacob Tondreau, Megan Yeckley, Wei Wei, Michael R. Howitt, Mark D. Parker, Jason A. Sprowl, Stephen M. Hinshaw, Jonathan Z. Long·· 19 hours agoPickScore79
MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss
In brief
The orphan transporter MCT6 is the key route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking intestinal MCT6 cannot maintain normal circulating Lac-Phe levels and are resistant to metformin-associated weight loss, establishing metabolite export as a regulatory node for systemic action.
Why it matters
The study establishes intestinal MCT6 export of Lac-Phe as a key mechanism of metformin-associated weight loss and a new node of metabolite-mediated systemic metabolic control.
Source: cell.com · cell.com