bioRxiv Cancer Biology· Jardine, J., Le Guyon, M., Trillet, K., Lacquemant, A., Verdu, I., Sagheer, T., Merlet, L., Moreau, R., Andre-Gregoire, G., Kerherve, M., Guillonneau, F., Bastiat, G., Gavard, J., Bidere, N. ·· 21 hours agoScore64
Molecular glue degraders of CK1α remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells
In brief
Selective CK1α molecular glue degraders induce CK1α degradation in glioblastoma stem-like cells, reshaping the abundance and maturation of late endosome-lysosome-associated proteins and reducing tumorsphere formation capacity. These degraders did not enhance LLOMe-induced lysosomal membrane permeabilization, yet they protected cells from ferroptosis induced by GPX4 inhibitors.
Source: bioRxiv Cancer Biology · biorxiv.org